GASTRO-PROTECTIVE EFFECT OF ROOT EXTRACT OF BARLERIA BUXIFOLIA ON ASPIRIN INDUCED GASTRIC ULCER IN RATS
DOI:
https://doi.org/10.25004/IJPSDR.2024.160204Keywords:
Barleria buxifolia, Aspirin, Anti-Oxidant Enzyme, Pro-Inflammatory Cytokines, RanitidineAbstract
The key assessment of the study was evaluating the gastro-protective properties of Barleria buxifolia root extract (REBB) in ulcerative rats. The roots of Barleria buxifolia have properties like antioxidant, anti-inflammatory, and other health benefits. Induction of gastric ulcers was done with aspirin (150 mg/kg, b.w., p.o) for 3 days and was accompanied by treatment with REBB (200 & 400 mg/kg orally) for 15 days. Ranitidine (20 mg/kg, orally) was received as the standard treatment for 14 days. Ulcer index, percent inhibition of ulceration, lipid peroxidation (LPO), TNF-α levels, and histopathological examination of the gastric mucosa were measured. Aspirin-induced stomach ulcers were seen in 100% of the groups, whereas other animal groups, aside from the control group possessed relatively comparable inductions. Ulcer number, ulcer index (p<0.01), and LPO (p<0.05) shown significant reduction in the 400mg/kg and Ranitidine (20mg/kg) when compared to Aspirin induced control group. Whereas the Ulcer score (p<0.001) and TNF-α (p<0.05) showed significant reduction in Ranitidine treated group but showed objectively improvement but statistically non-significant results in 200mg/kg and 400mg/kg REBB. Hence it was found that Baleria buxifolia root extract effectively mitigates aspirin-induced gastric ulceration in rats, underscoring its potential as a gastro protective agent.
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