POLYSACCHARIDE BASED CONTROLLED RELEASE MUCOADHESIVE DRUG DELIVERY SYSTEM FOR PAIN MANAGEMENT

Authors

  • Nidhi Namdev Faculty of Pharmacy, Medi-Caps University, Indore, Madhya Pradesh, India
  • Mousumi Kar Pillai Faculty of Pharmacy, Medi-Caps University, Indore, Madhya Pradesh, India
  • Sujit Pillai Pillai GRY Institute of Pharmacy, Borawan, Dist. Khargone, Madhya Pradesh, India
  • Ruchita Raghuvanshi GRY Institute of Pharmacy, Borawan, Dist. Khargone, Madhya Pradesh, India
  • Ujjawal Ahirwal GRY Institute of Pharmacy, Borawan, Dist. Khargone, Madhya Pradesh, India
  • R Yadav GRY Institute of Pharmacy, Borawan, Dist. Khargone, Madhya Pradesh, India

DOI:

https://doi.org/10.25004/IJPSDR.2024.160210

Keywords:

Mucoadhesive, Analgesia, Tramadol hydrochloride, Chitosan

Abstract

Mucoadhesion is one of the most extensively studied methods for the administration of medication for faster onset of action with enhanced bioavailability. Present investigation was concerned with the development and characterization of controlled release muco-adhesive drug delivery system for the drug Tramadol Hydrochloride (TRD) to extend the duration of analgesia for patients suffering from acute to chronic pain. Formulations were made using the solvent casting technique, incorporating natural polymers like Guar Gum, Xanthum Gum and Chitosan in conjunction with HPMC (hydroxy propyl methyl cellulose) to modify the drug release. The compatibility of film components were validated by Fourier Transform Infra- Red (FTIR) spectroscopy and subjected to physico-chemical evaluation parameters and ex-vivo drug diffusion study. Optimized formulation was tested for analgesic efficacy in vivo to determine extent of their suitability in therapeutic use. All the prepared formulations exhibited superior pharmaceutical qualities with respect to drug content, folding endurance, swelling index and mucoadhesion time. In ex-vivo drug diffusion study, all the films displayed a controlled release lasting longer than eight hours. Formulations containing Chitosan in combination with HPMC (F6) showed better controlled drug release over other combinations. The formulation F6 bring out remarkable in vivo analgesic efficacy with 58.10 % analgesia in contrast to the standard (61.16%). It was deduced that Tramadol hydrochloride mucoadhesive films were found to be an effective treatment for moderate to severe pain with a quick onset and a lengthy half-life.

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Published

30-03-2024

Issue

Volume 16, Issue 2, 2024

Section

Research Article

License

Copyright (c) 2024 Nidhi Namdev Research Scholar, Medi-caps university, Mousumi Kar Pillai; Dr. Sujit Pillai; Ruchita Raghuvanshi; Ujjawal Ahirwal

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

“POLYSACCHARIDE BASED CONTROLLED RELEASE MUCOADHESIVE DRUG DELIVERY SYSTEM FOR PAIN MANAGEMENT”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 16, no. 2, Mar. 2024, pp. 206-12, https://doi.org/10.25004/IJPSDR.2024.160210.